The Gout Pathogenesis Cycle

The origin and development of Gout can be described in the cycle below starting from 0 – 6 and repeats from 1 – 6.

0. Hyperuricemia

Attack starts on the joint.

1. Tophus Formation

Crystals Forms and start depositing in joints.

2. Inflammation

White blood cells start attacking the joints.

3. Cell Breakdown

Crystals ‘pop’ the cell, damaging them.

4. Protein Released

Burst cells release proteins.

5. More Inflammation

Proteins call in more white blood cells thus more pain and inflammation.

6. Decreased pH

Proteins lower the pH thus enhancing crystallization.