Gout Pathogenesis Cycle
The Gout Pathogenesis Cycle
The origin and development of Gout can be described in the cycle below starting from 0 – 6 and repeats from 1 – 6.
Attack starts on the joint.
1. Tophus Formation
Crystals Forms and start depositing in joints.
White blood cells start attacking the joints.
3. Cell Breakdown
Crystals ‘pop’ the cell, damaging them.
4. Protein Released
Burst cells release proteins.
5. More Inflammation
Proteins call in more white blood cells thus more pain and inflammation.
6. Decreased pH
Proteins lower the pH thus enhancing crystallization.